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KMID : 0361020000430070724
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Korean Journal of Otolaryngology - Head and Neck Surgery
2000 Volume.43 No. 7 p.724 ~ p.730
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Expression of Eotaxin and RANTES mRNA in Nasal Polyps and Its Effect on Eosinophils
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Shin Seung-Heon
Cho Chang-Ho
Sohn Jin-Ho
Lee Sang-Heun
Heo Won-Wook
Ye Mi-Kyung
Park Jae-Yul
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Abstract
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Background and Objectives : Nasal Polyps usually develop in the ethmoidal and middle turbinate area,
often in relation to inflammatory conditions. But the exact etiology and pathogenesis are still under debate.
Histologically, the polyps are infiltracted by a number of inflammatory cells with eosinophil predominating
in most specimens, and it is suggested that the nasal polyp is an inflammatory growth that is controlled
by the local microenvironment. Eotaxin and RANTES have been postulated to be involved in the
recruitment and activeation of eosinophils to certain inflamed tissues. The purpose of this study is to
investigate eotaxin and RANTES mRNA expression in nasal polyps and its effect on tissue and nasal
eosinophils.
Materials and Methods : Seventeen allergic and 18 non-allergic nasal polyps were obtained
from an endoscopic sinus surgery and 8 normal inferior turbinates were also taken. Immunohistochemical
staining for eosinophil and RANTES and quantitative RT- PCRs for eotaxin mRNA expression were
performed.
Results : The eotaxin mRNA levels in allergic nasal polyps were 11.4 fold higher and
non-allergic polyps were 6.4 fold higher than the normal inferior turbinates. But the RANTES didn’t show
any differences among the three groups. Tissue eosinophilia and its activation were significantly correlated
with the eotaxin mRNA level but not with the RANTES level.
Conclusion : In nasal polyp, eosinophilic infiltration and activation is mainly correlated with the increased
eotaxin gene expression and, to some extent, with the case of RANTES.
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KEYWORD
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Nasal polyp, Eotaxin, RANTES, Eosinophil
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